High loading of polygenic risk for ADHD in children with comorbid aggression.

doi:10.1176/appi.ajp.2013.12081129

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Article

High loading of polygenic risk for ADHD in children with comorbid aggression.

The American journal of psychiatry - 1 Aug 2013

Hamshere Marian L, Langley Kate, Martin Joanna, Agha Sharifah Shameem, Stergiakouli Evangelia, Anney Richard J L, Buitelaar Jan, Faraone Stephen V, Lesch Klaus-Peter, Neale Benjamin M, Franke Barbara, Sonuga-Barke Edmund, Asherson Philip, Merwood Andrew, Kuntsi Jonna, Medland Sarah E, Ripke Stephan, Steinhausen Hans-Christoph, Freitag Christine, Reif Andreas, Renner Tobias J, Romanos Marcel, Romanos Jasmin, Warnke Andreas, Meyer Jobst, Palmason Haukur, Vasquez Alejandro Arias, Lambregts-Rommelse Nanda, Roeyers Herbert, Biederman Joseph, Doyle Alysa E, Hakonarson Hakon, Rothenberger Aribert, Banaschewski Tobias, Oades Robert D, McGough James J, Kent Lindsey, Williams Nigel, Owen Michael J, Holmans Peter, O'Donovan Michael C, Thapar Anita

Abstract excerpt

OBJECTIVE Although attention deficit hyperactivity disorder (ADHD) is highly heritable, genome-wide association studies (GWAS) have not yet identified any common genetic variants that contribute to risk. There is evidence that aggression or conduct disorder in children with ADHD indexes higher genetic loading and clinical severity. The authors examine whether common genetic variants considered en masse as...

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PMID: 23599091
DOI: 10.1176/appi.ajp.2013.12081129
PMCID: PMC3935265

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