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Article

Common and rare genetic variants explain distinct diagnostic variance in pediatric attention deficit hyperactivity disorder.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Dec 2025

Arnett Anne B, Koesterer Ryan, Tovar Paulina Gonzalez, O'Connell Mia, Patel Soleha, Zhang Han, French Courtney E, Rockowitz Shira, Flannick Jason, Doan Ryan

Abstract excerpt

PURPOSE: Pediatric attention deficit hyperactivity disorder (ADHD, OMIM 143465) is highly heritable, yet the genetic architecture of the condition remains poorly understood. This study tested the hypothesis that rare and common genetic variants reflect distinct genetic pathways to ADHD. METHODS: Genome sequencing was completed for 150 pediatric ADHD cases and 370 controls. ADHD polygenic scores were derived and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41076565
DOI: 10.1016/j.gim.2025.101598
PMCID: PMC12637209

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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