Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.

doi:10.1038/s41467-020-20443-2

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Article

Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder.

Nature communications - 25 Jan 2021

Demontis Ditte, Walters Raymond K, Rajagopal Veera M, Waldman Irwin D, Grove Jakob, Als Thomas D, Dalsgaard Søren, Ribasés Marta, Bybjerg-Grauholm Jonas, Bækvad-Hansen Maria, Werge Thomas, Nordentoft Merete, Mors Ole, Mortensen Preben Bo, Cormand Bru, Hougaard David M, Neale Benjamin M, Franke Barbara, Faraone Stephen V, Børglum Anders D

Abstract excerpt

Attention-Deficit/Hyperactivity Disorder (ADHD) is a childhood psychiatric disorder often comorbid with disruptive behavior disorders (DBDs). Here, we report a GWAS meta-analysis of ADHD comorbid with DBDs (ADHD + DBDs) including 3802 cases and 31,305 controls. We identify three genome-wide significant loci on chromosomes 1, 7, and 11. A meta-analysis including a Chinese cohort supports that the locus on...

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PMID: 33495439
DOI: 10.1038/s41467-020-20443-2
PMCID: PMC7835232

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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