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Article

Dynamic recruitment of microRNAs to their mRNA targets in the regenerating liver

18 Apr 2013

Abstract excerpt

BACKGROUND: Validation of physiologic miRNA targets has been met with significant challenges. We employed HITS-CLIP to identify which miRNAs participate in liver regeneration, and to identify their target mRNAs. RESULTS: miRNA recruitment to the RISC is highly dynamic, changing more than five-fold for several miRNAs. miRNA recruitment to the RISC did not correlate with changes in overall miRNA expression for...

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PMID: 23597149
DOI: 10.1186/1471-2164-14-264

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