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Article

Genomewide microRNA down-regulation as a negative feedback mechanism in the early phases of liver regeneration

13 May 2011

Abstract excerpt

UNLABELLED: The liver is one of the few organs that have the capacity to regenerate in response to injury. We carried out genomewide microRNA (miRNA) microarray studies during liver regeneration in rats after 70% partial hepatectomy (PH) at early and mid time points to more thoroughly understand their role. At 3, 12, and 18 hours post-PH ∼40% of the miRNAs tested were up-regulated. Conversely, at 24 hours...

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PMID: 21574170
DOI: 10.1002/hep.24421

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