Article

miRNA activity inferred from single cell mRNA expression

2020-07-14

Abstract excerpt

High throughput single-cell RNA sequencing (scRNAseq) can provide mRNA expression profiles for thousands of cells. However, miRNAs cannot currently be studied at the same scale. By exploiting that miRNAs bind well-defined sequence motifs and typically down-regulate target genes, we show that motif enrichment analysis can be used to derive miRNA activity estimates from scRNAseq data. Motif enrichment analyses have...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99da2226-cadf-54c9-9574-62f6f5c61749
DOI: 10.1101/2020.07.14.202051

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

miRNA activity inferred from single cell mRNA expressionDOI 10.1101/2020.07.14.202051Read

miRSCAPE - Inferring miRNA expression in single-cell clustersSemantic proximity Read

bayesReact: Expression-coupled regulatory motif analysis detects microRNA activity in cancer and at the single cell levelSemantic proximity Read

Inferring single-cell and spatial microRNA activity from transcriptomics dataSemantic proximity Read

MixMir: microRNA motif discovery from gene expression data using mixed linear modelsSemantic proximity Read

Exploiting variability of single cells to uncover the in vivo hierarchy of miRNA targetsSemantic proximity Read

Towards the human cellular microRNAomeSemantic proximity Read

Predicting the Effect of miRNA on Gene Regulation to Foster Translational Multiomics Research – A Thorough Review on the Role of ChIP-Seq DataSemantic proximity Read

Benchmarking microRNA Target Prediction Algorithms Using Single-Cell Co-Sequencing DataSemantic proximity Read

mirCCC: Repression-aware graph learning for miRNA-mediated cell-cell communication inferenceSemantic proximity Read

Single-cell microRNA/mRNA co-sequencing reveals non-genetic heterogeneity and novel regulatory mechanismsSemantic proximity Read

Analysis of coding gene expression from small RNA sequencingSemantic proximity Read

A curated human cellular microRNAome based on 196 primary cell typesSemantic proximity Read