Article

PARP1, TRPM2 and redox signalling in hypertension-associated vascular dysfunction

2018-01-01

Abstract excerpt

While oxidative stress and dysregulation of Ca2+ homeostasis in vascular signalling are hallmarks of hypertension-associated vascular injury, downstream molecular mechanisms that govern reactive oxygen species (ROS)-dependent regulation of ion channels in hypertension are complex and have not yet been fully elucidated. Activation of poly(ADPribose)-polymerase 1 (PARP1) in response to oxidative stress and DNA damag...

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Literature Corpus work: 459d2e14-72f0-5001-8630-ca8c66b11ca2
DOI: 10.5525/gla.thesis.30660

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