Article
The case-only test for gene-environment interaction is not uniformly powerful: an empirical example.
Genetic epidemiology - 1 May 2013
Wu Chen, Chang Jiang, Ma Baoshan, Miao Xiaoping, Zhou Yifeng, Liu Yu, Li Yun, Wu Tangchun, Hu Zhibin, Shen Hongbing, Jia Weihua, Zeng Yixin, Lin Dongxin, Kraft Peter
Abstract excerpt
The case-only test has been proposed as a more powerful approach to detect gene-environment (G × E) interactions. This approach assumes that the genetic and environmental factors are independent. Although it is well known that Type I error rate will increase if this assumption is violated, it is less widely appreciated that G × E correlation can also lead to power loss. We illustrate this phenomenon by comparing...
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