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Article

Exposure Enriched Case-Control (EECC) Design for the Assessment of Gene-Environment Interaction.

Genetic epidemiology - 1 Nov 2016

Huque Md Hamidul, Carroll Raymond J, Diao Nancy, Christiani David C, Ryan Louise M

Abstract excerpt

Genetic susceptibility and environmental exposure both play an important role in the aetiology of many diseases. Case-control studies are often the first choice to explore the joint influence of genetic and environmental factors on the risk of developing a rare disease. In practice, however, such studies may have limited power, especially when susceptibility genes are rare and exposure distributions are highly...

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Identifiers

PMID: 27313007
DOI: 10.1002/gepi.21986
PMCID: PMC5069109

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