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Article

Unconditional analyses can increase efficiency in assessing gene-environment interaction of the case-combined-control design.

International journal of epidemiology - 1 Aug 2006

Goldstein Alisa M, Dondon Marie-Gabrielle, Andrieu Nadine

Abstract excerpt

BACKGROUND: A design combining both related and unrelated controls, named the case-combined-control design, was recently proposed to increase the power for detecting gene-environment (GxE) interaction. Under a conditional analytic approach, the case-combined-control design appeared to be more efficient and feasible than a classical case-control study for detecting interaction involving rare events. METHODS: We...

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Identifiers

PMID: 16556643
DOI: 10.1093/ije/dyl048
PMCID: PMC2080880

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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