Likelihood ratio test for detecting gene (G)-environment (E) interactions under an additive risk model exploiting G-E independence for case-control data.

Abstract excerpt

There has been a long-standing controversy in epidemiology with regard to an appropriate risk scale for testing interactions between genes (G) and environmental exposure (E ). Although interaction tests based on the logistic model-which approximates the multiplicative risk for rare diseases-have been more widely applied because of its convenience in statistical modeling, interactions under additive risk models...

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