Article
The genetic basis of parallel and divergent phenotypic responses in evolving populations of Escherichia coli.
Proceedings. Biological sciences - 7 Feb 2008
Ostrowski Elizabeth A, Woods Robert J, Lenski Richard E
Abstract excerpt
Pleiotropy plays a central role in theories of adaptation, but little is known about the distribution of pleiotropic effects associated with different adaptive mutations. Previously, we described the phenotypic effects of a collection of independently arising beneficial mutations in Escherichia coli. We quantified their fitness effects in the glucose environment in which they evolved and their pleiotropic effects...
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