The genetic basis of parallel and divergent phenotypic responses in evolving populations of Escherichia coli.

Abstract excerpt

Pleiotropy plays a central role in theories of adaptation, but little is known about the distribution of pleiotropic effects associated with different adaptive mutations. Previously, we described the phenotypic effects of a collection of independently arising beneficial mutations in Escherichia coli. We quantified their fitness effects in the glucose environment in which they evolved and their pleiotropic effects...

Topics

• Adaptation, Biological
• Analysis of Variance
• Bacterial Proteins
• Cluster Analysis
• Escherichia coli
• Evolution, Molecular
• Genotype
• Mutation
• Phenotype
• Pyrophosphatases
• Repressor Proteins