Article
Epitope recognition in HLA-DR3 transgenic mice immunized to TSH-R protein or peptides.
Endocrinology - 1 Jun 2013
Inaba Hidefumi, Moise Leonard, Martin William, De Groot Anne S, Desrosiers Joe, Tassone Ryan, Buchman George, Akamizu Takashi, De Groot Leslie J
Abstract excerpt
Development of Graves' disease is related to HLA-DR3. The extracellular domain (ECD) of human TSH receptor (hTSH-R) is a crucial antigen in Graves' disease. hTSH-R peptide 37 (amino acids 78-94) is an important immunogenic peptide in DR3 transgenic mice immunized to hTSH-R. This study examined the epitope recognition in DR3 transgenic mice immunized to hTSH-R protein and evaluated the ability of a mutant hTSH-R...
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