Article
Diversity in the complementarity-determining region 3 (CDR3) of antibodies from mice with evolving anti-thyroid-stimulating hormone receptor antibody responses.
Endocrinology - 1 Feb 2007
Martinez Osvaldo, Gangi Eryn, Mordi David, Gupta Sonal, Dorevitch Samuel, Lefranc Marie-Paule, Prabhakar Bellur S
Abstract excerpt
In a mouse model of autoimmune Graves' disease, stimulatory anti-TSH receptor (TSHR) antibodies (TSAbs) slowly evolve upon repeated immunization with TSHR and lead to hyperthyroidism. Although all immunized mice developed high levels of TSH-binding inhibitory Ig (TBII), only a subset of these mice become hyperthyroid, suggesting that the generation of pathogenic antibodies (Abs) may require affinity maturation....
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