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Article

Tg.2098 is a major human thyroglobulin T-cell epitope.

Journal of autoimmunity - 1 Aug 2010

Menconi Francesca, Huber Amanda, Osman Roman, Concepcion Erlinda, Jacobson Eric M, Stefan Mihaela, David Chela S, Tomer Yaron

Abstract excerpt

An HLA-DR variant containing Arginine at position 74 of the DRbeta1 chain confers a strong genetic susceptibility to autoimmune thyroid diseases (AITD), Graves' disease (GD) and Hashimoto's thyroiditis (HT), while Glutamine at position DRbeta1-74 is protective. We hypothesized that the DRbeta1-Arg74 variant is able to present pathogenic thyroglobulin (Tg) peptides to T-cells more efficiently, thereby triggering...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Histocompatibility Antigens Class II

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Share to Thyroiditis, Autoimmune

Source

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Identifiers

PMID: 20303712
DOI: 10.1016/j.jaut.2010.01.004
PMCID: PMC2878895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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