Immunization with the "immunogenic peptide" of TSH receptor induces oligoclonal antibodies with various biological activities.

doi:10.1016/s0196-9781(98)00092-8

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Article

Immunization with the "immunogenic peptide" of TSH receptor induces oligoclonal antibodies with various biological activities.

Peptides - 1 Jan 1998

Sugawa H, Ueda Y, Ueda M, Kosugi S, Ichiyama S, Mori T

Abstract excerpt

Balb/c mice were immunized with a synthetic peptide (P354-14) corresponding to "the immunogenic peptide" of human thyrotropin receptor (hTSH-R). Through screening for binding to the peptide, we obtained several monoclonal antibodies with various biological activities: thyroid stimulation (SAb), i...

Topics

Animals
Autoantibodies
Autoimmunity
COS Cells
Cyclic AMP
Epitopes
Humans
Mice
Mice, Inbred BALB C
Mutation
Peptides
Receptors, Thyrotropin
Thyroid Gland
Thyrotropin
Transfection

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