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Article

Blood tolerant laccase by directed evolution.

Chemistry & biology - 21 Feb 2013

Mate Diana M, Gonzalez-Perez David, Falk Magnus, Kittl Roman, Pita Marcos, De Lacey Antonio L, Ludwig Roland, Shleev Sergey, Alcalde Miguel

Abstract excerpt

High-redox potential laccases are powerful biocatalysts with a wide range of applications in biotechnology. We have converted a thermostable laccase from a white-rot fungus into a blood tolerant laccase. Adapting the fitness of this laccase to the specific composition of human blood (above neutral pH, high chloride concentration) required several generations of directed evolution in a surrogate complex blood...

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Identifiers

PMID: 23438751
DOI: 10.1016/j.chembiol.2013.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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