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Article

Loss of the B-lineage-specific gene expression program in Hodgkin and Reed-Sternberg cells of Hodgkin lymphoma.

Blood - 15 Feb 2003

Schwering Ines, Bräuninger Andreas, Klein Ulf, Jungnickel Berit, Tinguely Marianne, Diehl Volker, Hansmann Martin-Leo, Dalla-Favera Riccardo, Rajewsky Klaus, Küppers Ralf

Abstract excerpt

Hodgkin and Reed-Sternberg (HRS) cells represent the malignant cells in classical Hodgkin lymphoma (HL). Because their immunophenotype cannot be attributed to any normal cell of the hematopoietic lineage, the origin of HRS cells has been controversially discussed, but molecular studies established their derivation from germinal center B cells. In this study, gene expression profiles generated by serial analysis...

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Share to B-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oligonucleotide Array Sequence Analysis

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Share to Receptors, Antigen, B-Cell

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Source

Identifiers

PMID: 12393731
DOI: 10.1182/blood-2002-03-0839

Genes

BCR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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