Molecular biology of Hodgkin lymphoma.

Abstract excerpt

Classical Hodgkin lymphoma (cHL) is unique among lymphoid malignancies in several key biological features. (i) The Hodgkin and Reed-Sternberg (HRS) tumor cells are rare among an extensive and complex microenvironment. (ii) They derive from B cells, but have largely lost the B-cell typical gene expression program. (iii) Their specific origin appears to be pre-apoptotic germinal center (GC) B cells. (iv) They...

Topics

• Animals
• B-Lymphocytes
• Biomarkers, Tumor
• Cell Transformation, Neoplastic
• Disease Management
• Disease Susceptibility
• Gene Expression Regulation, Neoplastic
• Genetic Predisposition to Disease
• Genetic Variation
• Hodgkin Disease
• Humans