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Article

ULK1-mediated phosphorylation of ATG14 promotes autophagy and is impaired in Huntington’s disease models

1 Dec 2016

Abstract excerpt

BACKGROUND: Autophagy is a bulk degradation pathway for long-lived proteins, protein aggregates, and damaged organelles. ULK1 protein kinase and Vps34 lipid kinase are two key autophagy regulators that are critical for autophagosome biogenesis. However, it isn't fully understood how ULK1 regulates Vps34, especially in the context of disease. Polyglutamine expansion in huntingtin (Htt) causes aberrant accumulation...

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PMID: 27938392
DOI: 10.1186/s13024-016-0141-0

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