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Article

Polyglutamine tracts regulate beclin 1-dependent autophagy.

Nature - 4 May 2017

Ashkenazi Avraham, Bento Carla F, Ricketts Thomas, Vicinanza Mariella, Siddiqi Farah, Pavel Mariana, Squitieri Ferdinando, Hardenberg Maarten C, Imarisio Sara, Menzies Fiona M, Rubinsztein David C

Abstract excerpt

Nine neurodegenerative diseases are caused by expanded polyglutamine (polyQ) tracts in different proteins, such as huntingtin in Huntington's disease and ataxin 3 in spinocerebellar ataxia type 3 (SCA3). Age at onset of disease decreases with increasing polyglutamine length in these proteins and the normal length also varies. PolyQ expansions drive pathogenesis in these diseases, as isolated polyQ tracts are...

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Identifiers

PMID: 28445460
DOI: 10.1038/nature22078
PMCID: PMC5420314

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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