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Article

Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model.

Journal of molecular neuroscience : MN - 1 Jun 2012

Yu Xin, Ajayi Abiodun, Boga Narasimha Rao, Ström Anna-Lena

Abstract excerpt

Spinocerebellar ataxia type 7 (SCA7) is one of nine neurodegenerative disorders caused by expanded polyglutamine repeats, and a common toxic gain-of-function mechanism has been proposed. Proteolytic cleavage of several polyglutamine proteins has been identified and suggested to modulate the polyg...

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Identifiers

PMID: 22367614
DOI: 10.1007/s12031-012-9722-8
PMCID: PMC3360856

Genes

ATXN7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-22367614-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

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Differential degradation of full-length and cleaved ataxin-7 fragments in a novel stable inducible SCA7 model.PMID 22367614Read ↗

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