Article
Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells.
International journal of oncology - 1 Aug 2007
Tanaka Hiroaki, Yoshida Kaya, Okamura Hirohiko, Morimoto Hiroyuki, Nagata Toshihiko, Haneji Tatsuji
Abstract excerpt
Previously, we reported that okadaic acid, a specific inhibitor of serine/threonine protein phosphatases, induced apoptosis in human osteoblastic cells. However, it is not clear whether calyculin A, another inhibitor of protein phosphatases, would induce apoptosis in human osteoblastic cells and if so, which mechanisms are involved and whether the phosphorylation status of NF-kappaB could be affected by the...
Topics
- Apoptosis
- Binding Sites
- Bone Neoplasms
- Cell Line, Tumor
- Cell Survival
- Enzyme Inhibitors
- Humans
- Marine Toxins
- Mutation
- Osteoblasts
- Osteosarcoma
- Oxazoles
- Phosphorylation
- Serine
- Transcription Factor RelA
- Transcription, Genetic