Bergmann glia require continuous association with Purkinje cells for normal phenotype expression.

doi:10.1002/glia.440080305

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Article

Bergmann glia require continuous association with Purkinje cells for normal phenotype expression.

Glia - 1 Jul 1993

Fisher M, Trimmer P, Ruthel G

Abstract excerpt

Bergmann glia (Bg) respond to the early postnatal Purkinje cell (Pc) death in Lurcher (Lc) mutant mouse cerebellum by down-regulating expression of the enzyme glycerol-3-phosphate dehydrogenase (GPDH). To determine whether glial GPDH expression requires the continued presence of Pcs in adults, we used single intracerebellar injections of kainic acid to kill Pcs in wild-type mice from 7 weeks to 11 months old. Bg...

Topics

Age Factors
Animals
Apoptosis
Brain Tissue Transplantation
Cell Communication
Cell Death
Cerebellum
Dendrites
Enzyme Induction
Fetal Tissue Transplantation
Glycerolphosphate Dehydrogenase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Kainic Acid

Mice

Mice, Neurologic Mutants

Nerve Tissue Proteins

Neuroglia

Phenotype

Purkinje Cells

Source

Open in PubMed

Identifiers

PMID: 8225559
DOI: 10.1002/glia.440080305

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8225559-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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