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Article

Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia

15 Apr 2013

Abstract excerpt

Notch regulates cell-cell contact-dependent signaling and is activated by hypoxia, a microenvironmental condition that promotes cellular invasion during both normal physiology and disease. The mechanisms by which hypoxia and Notch regulate cellular invasion are not fully elucidated. In this paper, we show that, in cancer cells, hypoxia increased the levels and activity of the ADAM12 metalloprotease in a Notch...

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PMID: 23589494
DOI: 10.1083/jcb.201209151

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