Article
Higher frequency of genetic variants conferring increased risk for ADRs for commonly used drugs treating cancer, AIDS and tuberculosis in persons of African descent.
The pharmacogenomics journal - 1 Apr 2014
Aminkeng F, Ross C J D, Rassekh S R, Brunham L R, Sistonen J, Dube M-P, Ibrahim M, Nyambo T B, Omar S A, Froment A, Bodo J-M, Tishkoff S, Carleton B C, Hayden M R
Abstract excerpt
There is established clinical evidence for differences in drug response, cure rates and survival outcomes between different ethnic populations, but the causes are poorly understood. Differences in frequencies of functional genetic variants in key drug response and metabolism genes may significantly influence drug response differences in different populations. To assess this, we genotyped 1330 individuals of...
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