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Pharmacogenomics in Africa: A Potential Catalyst for Precision Medicine in Genetically Diverse Populations.

Annual review of genomics and human genetics - 1 Aug 2025

Twesigomwe David, Mazhindu Tinashe A, Nagy Mohamed, Agesa Gaye, Scholefield Janine, Masimirembwa Collen

Abstract excerpt

Genetic variation is a major determinant of drug response across populations. Owing to advances in sequencing technologies over the last two decades, several clinically actionable variants or haplotypes have been characterized in genes that encode proteins mediating drug pharmacokinetics or pharmacodynamics. Therefore, clinical application of pharmacogenomics has gained significant traction as a promising tool...

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PMID: 40146997
DOI: 10.1146/annurev-genom-121323-104008

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