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Unique mutations in mitochondrial DNA of senescence-accelerated mouse (SAM) strains.

The Journal of heredity - 1 Jan 2000

Mizutani J, Chiba T, Tanaka M, Higuchi K, Mori M

Abstract excerpt

Mitochondrial DNA (mtDNA) is exclusively inherited maternally and hence could offer a good method for tracing the lineage of mouse strains. We examined the mtDNA sequence of senescence-accelerated mouse (SAM) strains as well as other laboratory strains of inbred mice to deduce the ancestral strain of SAM. Four unique mutations were identified at bases 2256, 10,847, 11,181, and 13,053 in SAM strains. The mutations...

Topics

Aging
Aging, Premature
Animals
Consensus Sequence
DNA, Mitochondrial
Mice
Mice, Inbred Strains
Mitochondria
Molecular Sequence Data
Mutation
Polymerase Chain Reaction

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Genetic

Source

Identifiers

PMID: 11535650
DOI: 10.1093/jhered/92.4.352

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