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Article

Senescence-accelerated mouse (SAM): a biogerontological resource in aging research.

Neurobiology of aging - 1 Jan 2000

Takeda T

Abstract excerpt

The senescence-accelerated mouse (SAM), consisting of 14 senescence-prone inbred strains (SAMP) and 4 senescence-resistant inbred strains (SAMR) has been under development since 1970 through the selective inbreeding of AKR/J strain mice donated by the Jackson laboratory in 1968, based on the data of the grading score of senescence, life span, and pathologic phenotypes. The characteristic feature of aging common...

Topics

Aging
Amyloidosis
Animals
Disease Models, Animal
Geriatrics
Joint Diseases
Mice
Mice, Inbred Strains
Osteoporosis
Phenotype

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 10537019
DOI: 10.1016/s0197-4580(99)00008-1

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