Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Delerue Fabien, Sjollema Geoff, Whittle Belinda, Krüger Sarah, Andrews Dan, Götz Jürgen

Abstract excerpt

One of the major challenges in neurodegenerative research is modeling systemic aging. Here, senescence-accelerated mice such as the multigenic SAMP8 (senescence accelerated prone 8) mice are useful as they are characterized by an early manifestation of senescence that includes a shortened lifespan and impaired brain and immune functions. While SAMP8 mice are widely used tools to address aging and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aging
Share to DNA, Recombinant
Share to Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C57BL

Share to Mice, Mutant Strains

Share to Models, Animal

Share to Nucleotides

Share to Sequence Analysis, DNA

Source

Identifiers

PMID: 23609764
DOI: 10.3233/JAD-130089

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single nucleotide variants (SNVs) define senescence-accelerated SAMP8 mice, a model of a geriatric condition.PMID 23609764Read ↗

Exome sequencing of senescence-accelerated mice (SAM) reveals deleterious mutations in degenerative disease-causing genes.Semantic proximity Read ↗

Single-Nucleotide Polymorphisms Associated with the Senescence-Accelerated Phenotype of OXYS Rats: A Focus on Alzheimer's Disease-Like and Age-Related-Macular-Degeneration-Like Pathologies.Semantic proximity Read ↗

The senescence-accelerated prone mouse (SAMP8): A model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's diseaseSemantic proximity Read ↗

Genome-wide identification of functional tRNA-derived fragments in Senescence-accelerated mouse prone 8 brainSemantic proximity Read ↗

From Aging to Alzheimer's Disease: Unveiling “The Switch” with the Senescence-Accelerated Mouse Model (SAMP8)Semantic proximity Read ↗

Whole-Genome Sequencing of a Healthy Aging Cohort.Semantic proximity Read ↗

Nodes and biological processes identified on the basis of network analysis in the brain of the senescence accelerated mice as an Alzheimer's disease animal modelSemantic proximity Read ↗

Genome-wide analysis of DNA methylation profiles in a senescence-accelerated mouse prone 8 brain using whole-genome bisulfite sequencingSemantic proximity Read ↗

Mechanisms of aging in senescence-accelerated mice.Semantic proximity Read ↗

The behavioral, pathological and therapeutic features of the senescence-accelerated mouse prone 8 strain as an Alzheimer's disease animal model.Semantic proximity Read ↗

Senescence-related genes and proteins in the development of Alzheimer’s disease: evidence from transcriptomic and Mendelian randomization analysisSemantic proximity Read ↗

Brain Somatic Mutation in Aging and Alzheimer's Disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.