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Article

Increase in lamin B1 promotes telomere instability by disrupting the shelterin complex in human cells

1 Sept 2021

Abstract excerpt

Telomere maintenance is essential to preserve genomic stability and involves telomere-specific proteins, DNA replication and repair proteins. Lamins are key components of the nuclear envelope and play numerous roles, including maintenance of the nuclear integrity, regulation of transcription, and DNA replication. Elevated levels of lamin B1, one of the major lamins, have been observed in some human pathologies...

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Share to DNA Repair Mechanisms
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34469544
DOI: 10.1093/nar/gkab761

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