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Article

A single residue substitution in the receptor-binding domain of H5N1 hemagglutinin is critical for packaging into pseudotyped lentiviral particles.

PloS one - 1 Jan 2012

Tang Dong-Jiang, Lam Yuen-Man, Siu Yu-Lam, Lam Chi-Hong, Chu Shui-Ling, Peiris J S Malik, Buchy Philippe, Nal Béatrice, Bruzzone Roberto

Abstract excerpt

BACKGROUND: Serological studies for influenza infection and vaccine response often involve microneutralization and hemagglutination inhibition assays to evaluate neutralizing antibodies against human and avian influenza viruses, including H5N1. We have previously characterized lentiviral particles pseudotyped with H5-HA (H5pp) and validated an H5pp-based assay as a safe alternative for high-throughput serological...

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Identifiers

PMID: 23133587
DOI: 10.1371/journal.pone.0043596
PMCID: PMC3487904

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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