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Article

Deacetylation of the DNA-binding Domain Regulates p53-mediated Apoptosis

10 Dec 2010

Abstract excerpt

In unstressed cells, the p53 tumor suppressor is highly unstable. DNA damage and other forms of cellular stress rapidly stabilize and activate p53. This process is regulated by a complex array of post-translational modifications that are dynamically deposited onto p53. Recent studies show that these modifications orchestrate p53-mediated processes such as cell cycle arrest and apoptosis. Cancer cells carry...

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PMID: 21148320
DOI: 10.1074/jbc.m110.184663

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