Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing Radiation

17 May 2016

Abstract excerpt

Persistent DNA damage is considered as a main cause of cellular senescence induced by ionizing radiation. However, the molecular bases of the DNA damage and their contribution to cellular senescence are not completely clear. In this study, we found that both heavy ions and X-rays induced senescence in human uveal melanoma 92-1 cells. By measuring senescence associated-β-galactosidase and cell proliferation, we...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogens and Genotoxicity Assessment
Share to DNA Repair Mechanisms
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27187621
DOI: 10.1371/journal.pone.0155725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Both Complexity and Location of DNA Damage Contribute to Cellular Senescence Induced by Ionizing RadiationPMID 27187621Read ↗

The Molecular Mechanisms in Senescent Cells Induced by Natural Aging and Ionizing RadiationSemantic proximity Read ↗

Radiation-induced accelerated senescenceSemantic proximity Read ↗

Role of low-dose radiation in senescence and aging: A beneficial perspectiveSemantic proximity Read ↗

Senescence: A DNA damage response and its role in aging and Neurodegenerative DiseasesSemantic proximity Read ↗

High-LET-Radiation-Induced Persistent DNA Damage Response Signaling and Gastrointestinal Cancer DevelopmentSemantic proximity Read ↗

Interconnection between DNA damage senescence inflammation and cancerSemantic proximity Read ↗

The accumulation of DNA repair defects is the molecular origin of carcinogenesis.Semantic proximity Read ↗

Replication-stress-associated DSBs induced by ionizing radiation risk genomic destabilization and associated clonal evolutionSemantic proximity Read ↗

Ionizing irradiation inhibits keloid fibroblast cell proliferation and induces premature cellular senescenceSemantic proximity Read ↗

The importance of senescence in ionizing radiation-induced tumour suppression.Semantic proximity Read ↗

Radiation-induced senescence: therapeutic opportunitiesSemantic proximity Read ↗

Unrepairable DNA double-strand breaks that are generated by ionising radiation determine the fate of normal human cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.