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Article

The C-terminus of Nej1 is critical for nuclear localization and non-homologous end-joining.

DNA repair - 1 Feb 2014

Mahaney Brandi L, Lees-Miller Susan P, Cobb Jennifer A

Abstract excerpt

Nej1 is an essential factor in the non-homologous end-joining (NHEJ) pathway and interacts with the DNA ligase complex, Lif1-Dnl4, through interactions with Lif1. We have mapped K331-V338 in the C-terminal region of Nej1 to be critical for its functionality during repair. Truncation and alanine scanning mutagenesis have been used to identify a motif in Nej1, KKRK (331-334), which is important for both nuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24369855
DOI: 10.1016/j.dnarep.2013.12.002
PMCID: PMC4122420

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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