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Article

Loss of habenular Prkar2a reduces hedonic eating and increases exercise motivation.

JCI insight - 3 Dec 2020

London Edra, Wester Jason C, Bloyd Michelle, Bettencourt Shelby, McBain Chris J, Stratakis Constantine A

Abstract excerpt

The habenula (Hb) is a bilateral, evolutionarily conserved epithalamic structure connecting forebrain and midbrain structures that has gained attention for its roles in depression, addiction, rewards processing, and motivation. Of its 2 major subdivisions, the medial Hb (MHb) and lateral Hb (LHb), MHb circuitry and function are poorly understood relative to those of the LHb. Prkar2a codes for cAMP-dependent...

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Source

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Identifiers

PMID: 33141766
DOI: 10.1172/jci.insight.141670
PMCID: PMC7714411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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