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Article

Selective defect of <i>in vivo</i> glycolysis in early Huntington's disease striatum

13 Feb 2007

Abstract excerpt

Activity of complexes II, III, and IV of the mitochondrial electron transport system (ETS) is reduced in postmortem Huntington's disease (HD) striatum, suggesting that reduced cerebral oxidative phosphorylation may be important in the pathogenesis of neuronal death. We investigated mitochondrial oxidative metabolism in vivo in the striatum of 20 participants with early, genetically proven HD and 15 age-matched...

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PMID: 17299049
DOI: 10.1073/pnas.0609833104

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