Article
Removal of a C-terminal serine residue proximal to the inter-chain disulfide bond of a human IgG1 lambda light chain mediates enhanced antibody stability and antibody dependent cell-mediated cytotoxicity.
mAbs - 1 Jan 2000
Shen Yang, Zeng Lin, Zhu Aiping, Blanc Tim, Patel Dipa, Pennello Anthony, Bari Amtul, Ng Stanley, Persaud Kris, Kang Yun Kenneth, Balderes Paul, Surguladze David, Hindi Sagit, Zhou Qinwei, Ludwig Dale L, Snavely Marshall
Abstract excerpt
Optimization of biophysical properties is a critical success factor for the developability of monoclonal antibodies with potential therapeutic applications. The inter-domain disulfide bond between light chain (Lc) and heavy chain (Hc) in human IgG1 lends structural support for antibody scaffold stability, optimal antigen binding, and normal Fc function. Recently, human IgG1λ has been suggested to exhibit...
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