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Comparing domain interactions within antibody Fabs with kappa and lambda light chains

25 Jul 2016

Abstract excerpt

IgG antibodies are multi-domain proteins with complex inter-domain interactions. Human IgG heavy chains (HCs) associate with light chains (LCs) of the κ or λ isotype to form mature antibodies capable of binding antigen. The HC/LC interaction involves 4 domains: VH and CH1 from the HC and VL and CL from the LC. Human Fabs with κ LCs have been well characterized for their unfolding behaviors and demonstrate a...

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PMID: 27454112
DOI: 10.1080/19420862.2016.1214785

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