Article
Elucidating a relationship between conformational sampling and drug resistance in HIV-1 protease.
Biochemistry - 14 May 2013
de Vera Ian Mitchelle S, Smith Adam N, Dancel Maria Cristina A, Huang Xi, Dunn Ben M, Fanucci Gail E
Abstract excerpt
Enzyme targets in rapidly replicating systems, such as retroviruses, commonly respond to drug-selective pressure with mutations arising in the active site pocket that limit inhibitor effectiveness by introducing steric hindrance or by eliminating essential molecular interactions. However, these primary mutations are disposed to compromising pathogenic fitness. Emerging secondary mutations, which are often found...
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