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Article

Darunavir-Resistant HIV-1 Protease Constructs Uphold a Conformational Selection Hypothesis for Drug Resistance.

Viruses - 8 Nov 2020

Liu Zhanglong, Tran Trang T, Pham Linh, Hu Lingna, Bentz Kyle, Savin Daniel A, Fanucci Gail E

Abstract excerpt

Multidrug resistance continues to be a barrier to the effectiveness of highly active antiretroviral therapy in the treatment of human immunodeficiency virus 1 (HIV-1) infection. Darunavir (DRV) is a highly potent protease inhibitor (PI) that is oftentimes effective when drug resistance has emerged against first-generation inhibitors. Resistance to darunavir does evolve and requires 10-20 amino acid substitutions....

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Identifiers

PMID: 33171603
DOI: 10.3390/v12111275
PMCID: PMC7695139

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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