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Article

Monoclonal antibody m18 paratope leading to dual receptor antagonism of HIV-1 gp120.

Biochemistry - 12 Apr 2011

Gift Syna Kuriakose, McFadden Karyn, Zentner Isaac J, Rajagopal Srivats, Zhang Mei-Yun, Dimitrov Dimiter S, Chaiken Irwin M

Abstract excerpt

We sought to identify sequences in the monoclonal antibody m18 complementarity determining regions (CDRs) that are responsible for its interaction with HIV-1 gp120 and inhibition of the envelope receptor binding sites. In the accompanying paper (DOI 10.1021/bi101160r), we reported that m18 inhibits CD4 binding through a nonactivating mechanism that, at the same time, induces conformational effects leading to...

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Source

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Identifiers

PMID: 21417283
DOI: 10.1021/bi101161j
PMCID: PMC3499988

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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