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Article

Prognostic impact and targeting of CRM1 in acute myeloid leukemia

6 Apr 2013

Abstract excerpt

Chromosomal region maintenance 1 (CRM1) is a nuclear export receptor recognizing proteins bearing a leucine-rich nuclear export signal. CRM1 is involved in nuclear export of tumor suppressors such as p53. We investigated the prognostic significance of CRM1 in acute myeloid leukemia (AML) and effects of a novel small-molecule selective inhibitor of CRM1. CRM1 protein expression was determined in 511 newly...

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PMID: 23564911
DOI: 10.1182/blood-2012-08-447581

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