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MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma

18 Jan 2022

Abstract excerpt

Abstract Colorectal cancer (CRC) is one of the most common and deadliest forms of cancer. Myeloid Cell Leukemia 1 (MCL1), a pro-survival member of the Bcl-2 protein family is associated with chemo-resistance in CRC. The ability of MCL1 to inhibit apoptosis by binding to the BH3 domains of pro-apoptotic Bcl-2 family members is a well-studied means by which this protein confers resistance to multiple anti-cancer...

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PMID: 35042842
DOI: 10.1038/s41419-021-04334-y

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