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Article

Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma.

Cancer science - 1 Jul 2014

Yoshimura Mariko, Ishizawa Jo, Ruvolo Vivian, Dilip Archana, Quintás-Cardama Alfonso, McDonnell Timothy J, Neelapu Sattva S, Kwak Larry W, Shacham Sharon, Kauffman Michael, Tabe Yoko, Yokoo Masako, Kimura Shinya, Andreeff Michael, Kojima Kensuke

Abstract excerpt

The nuclear transporter exportin-1 (XPO1) is highly expressed in mantle cell lymphoma (MCL) cells, and is believed to be associated with the pathogenesis of this disease. XPO1-selective inhibitors of nuclear export (SINE) compounds have been shown to induce apoptosis in MCL cells. Given that p53 is a cargo protein of XPO1, we sought to determine the significance of p53 activation through XPO1 inhibition in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24766216
DOI: 10.1111/cas.12430
PMCID: PMC4106990

Genes

XPO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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