Article
Frequency of the GPR7 Tyr135Phe allelic variant in lean and obese subjects.
Journal of endocrinological investigation - 1 Oct 2013
Pelosini C, Maffei M, Ceccarini G, Marchi M, Marsili A, Galli G, Scartabelli G, Tamberi A, Latrofa F, Fierabracci P, Vitti P, Pinchera A, Santini F
Abstract excerpt
BACKGROUND: GPR7, the endogenous coupled receptor for neuropeptide B and neuropeptide W, is expressed in several regions of the central nervous system, which are involved in the regulation of feeding behavior. GPR7 affects the regulation of energy balance through a mechanism independent of leptin and melanocortin pathways. AIM: Aim of this study was to investigate whether GPR7 gene mutations can be detected in...
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