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Article

Role of Transcription Factor NFAT in Glucose and Insulin Homeostasis

1 Oct 2006

Abstract excerpt

Compromised immunoregulation contributes to obesity and complications in metabolic pathogenesis. Here, we demonstrate that the nuclear factor of activated T cell (NFAT) group of transcription factors contributes to glucose and insulin homeostasis. Expression of two members of the NFAT family (NFATc2 and NFATc4) is induced upon adipogenesis and in obese mice. Mice with the Nfatc2-/- Nfatc4-/- compound disruption...

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Identifiers

PMID: 16908540
DOI: 10.1128/mcb.00580-06

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