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Article

A new genetically engineered mouse model of choroid plexus carcinoma.

Biochemical and biophysical research communications - 5 Feb 2018

El Nagar Salsabiel, Zindy Frederique, Moens Charlotte, Martin Luc, Plassard Damien, Roussel Martine F, Lamonerie Thomas, Billon Nathalie

Abstract excerpt

Choroid plexus carcinomas (CPCs) are highly malignant brain tumours predominantly found in children and associated to poor prognosis. Improved therapy for these cancers would benefit from the generation of animal models. Here we have created a novel mouse CPC model by expressing a stabilised form of c-Myc (MycT58A) and inactivating Trp53 in the choroid plexus of newborn mice. This induced aberrant proliferation...

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Identifiers

PMID: 29339161
DOI: 10.1016/j.bbrc.2017.11.192
PMCID: PMC5880203

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