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Article

Mycobacterium tuberculosis ClpP proteases are co-transcribed but exhibit different substrate specificities.

PloS one - 1 Jan 2013

Personne Yoann, Brown Amanda C, Schuessler Dorothée L, Parish Tanya

Abstract excerpt

Caseinolytic (Clp) proteases are widespread energy-dependent proteases; the functional ATP-dependent protease is comprised of multimers of proteolytic and regulatory subunits. Mycobacterium tuberculosis has two ClpP proteolytic subunits (ClpP1 and ClpP2), with both being essential for growth in vitro. ClpP1 and clpP2 are arranged in an apparent operon; we demonstrated that the two genes are co-expressed under...

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Identifiers

PMID: 23560081
DOI: 10.1371/journal.pone.0060228
PMCID: PMC3613350

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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