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Trapping and Identification of Cellular Substrates of the Staphylococcus aureus ClpC Chaperone

2 Aug 2013

Abstract excerpt

ClpC is an ATP-dependent Hsp100/Clp chaperone involved in protein quality control in low-GC Gram-positive bacteria. Previously, we found that ClpC affected the expression of a large number of genes, including capsule genes in Staphylococcus aureus. Here we constructed a His-tagged ClpC variant (ClpC(trap)) with mutations within the Walker B motifs to identify the direct substrates of ClpC by copurification with...

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PMID: 23913326
DOI: 10.1128/jb.00758-13

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